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   2014| January-April  | Volume 2 | Issue 1  
    Online since March 7, 2014

 
 
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INVITED ARTICLE
Prognostic and predictive markers for oral squamous cell carcinoma: The importance of clinical, pathological and molecular markers
Saman Warnakulasuriya
January-April 2014, 2(1):12-16
DOI:10.4103/1658-631X.128400  
The overall 5-year survival rate following treatment for oral squamous cell carcinoma is around 50% in most published series. The major prognostic factors are stage at the time of diagnosis, unexpected close margins at resection, depth and pattern of tissue invasion by carcinoma and extracapsular spread. Grading by gross histological differentiation does not influence prognosis, unless deeply invasive margins are evaluated by the pathologist. Because stage at diagnosis is the most important factor affecting outcome, early detection results in better prognosis in most cases.
  8,499 1,620 10
ORIGINAL ARTICLES
Urine Albumin/creatinine ratio: A reliable marker of renal injury in sickle cell nephropathy
Ibrahiem S Abdul-Rahman
January-April 2014, 2(1):17-23
DOI:10.4103/1658-631X.128403  
Objective: Albumin/creatinine ratio is a sensitive marker of glomerular damage in patients with diabetes mellitus, hypertension and post-infection glomerulonephritis. Whether or not the albumin/creatinine ratio has the same value in sickle cell anemia (SCA) patients is not yet explored. This study was conducted to determine the prevalence of glomerular damage in SCA and the clinical correlation between albumin/creatinine ratio and renal insufficiency in this group of patients. Materials and Methods: Seventy-nine adult patients with SCA (hemoglobin SS subtype) were included in this study. Albumin excretion rates (expressed as albumin/creatinine ratio) and renal function (creatinine clearance) were determined and clinical and hematologic evaluations were conducted. Results: Increased albumin/creatinine ratio (micro- and macroalbuminuria) occurred in 57% of the patients. The development of graded albuminuria was time dependent; therefore, at the end of the study, 26.6% of the patients had macroalbuminuria. There were no differences in hemoglobin levels between patients with normoalbuminuria and those with micro- or macroalbuminuria. By multivariate analysis, albuminuria correlated with age and creatinine clearance (Cr Cl) but not with blood pressure (BP) or hemoglobin levels. Conclusion: Albumin/creatinine ratio is a sensitive marker of glomerular damage in SCA patients, and it correlated well with Cr Cl; therefore, patients with abnormal albumin/creatinine ratio should be monitored closely for progression of renal disease. The development of micro- and macroalbuminuria is related to age but not to the degree of anemia, suggesting that sickle cell glomerulopathy is not solely related to hemodynamic adaptations to chronic anemia.
  7,346 537 -
IN FOCUS
Global plan for the decade of action for road safety: Expectations from developing nations
Saurabh R Shrivastava, Prateek S Shrivastava, Jegadeesh Ramasamy
January-April 2014, 2(1):57-58
DOI:10.4103/1658-631X.128456  
Globally, 1.24 million people die every year because of road traffic accidents (RTAs) and almost 20-50 million people sustain non-fatal injuries. Realizing the magnitude and the global distribution of the problem, the current decade 2011-2020 has been proclaimed as the Decade of Action for road safety, with a target of first stabilizing and then decreasing the estimated magnitude of morbidity and mortality by intensifying the global efforts on national and international platform. The primary step is to develop a surveillance network for data collection to identify the causative factors and estimate the accurate magnitude of RTA so that rational policy can be planned for achieving the best possible allocation of limited resources, especially in developing countries. Other measures such as creating public awareness; strict enforcement of road safety legislations; establishing prompt and good quality post-crash response; and establishing monitoring and evaluation system to assess the outcome of implemented measures can be strategically implemented to counter the burden of road traffic accidents.
  5,164 699 1
ORIGINAL ARTICLES
Physical and psychological aspects of low back pain among Saudi patients: A case-control study
Ali M Alshami
January-April 2014, 2(1):24-29
DOI:10.4103/1658-631X.128407  
Context: Low back pain (LBP) is a common public health problem, and has a multifactorial etiology that includes not only physical risk factors, but also psychosocial factors. There were several studies that investigated physical and psychosocial factors and their relationship with LBP. However, up to the researchers' knowledge, no studies have been conducted in Saudi Arabia. Aims: To investigate physical and psychological factors in Saudi population with LBP. Settings and Design: A case-control study using self-report measures. Materials and Methods: Arabic versions of the following self-report measures were applied: A 10-cm Visual Analogue Scale (VAS) to measure pain intensity; the International Physical Activity Questionnaire (IPAQ) to record average physical activity levels over the last 7 days; and Depression, Anxiety and Stress Scale (DASS) to measure the negative emotional states of depression, anxiety and stress. The above self-report measures were handed to the participants and were collected immediately. Thirty-one patients with LBP and thirty-one control participants matched in body mass index and age participated. Statistical analysis used: Independent t-tests and Pearson Correlation Analysis were used to calculate differences in VAS, IPAQ and DASS between the two groups. Results: Patients with LBP had moderate stress compared to control participants (19.8 and 4.4 respectively, P = 0.0013). Both groups did not present with anxiety or depression. No significant difference was found in any level of activity between the groups. Conclusions: Stress was present in this group of Saudi patients with LBP. Targeting psychological factors associated with LBP, not only physical factors may help improve the management of patients with LBP.
  5,012 482 2
Effect of time on electronic working length determination with a novel endodontic module in preclinical endodontic training
Emad O AlShwaimi, Udaya B Narayanaraopeta
January-April 2014, 2(1):37-42
DOI:10.4103/1658-631X.128451  
Aim: To evaluate electrical conductivity of the medium provided with ModuPRO endodontic modules, and compare it with those of alginate and vinyl polysiloxane impression materials over varying time intervals. Materials and Methods: A 24 Real Endo-t teeth were mounted in the ModuPRO Endo™ modules using three different mounting media [Groups A (Apex Putty), B (alginate), C (extra-light body vinyl polysiloxane)]. The working lengths were predetermined by microscopy, and the root canals were prepared with ProFile rotary instruments before mounting. Working lengths were checked with an electronic apex locator at 24 and 48 hours; 1, 4, and 6 weeks; and 6 months. Data were analyzed using one-way analysis of variance (ANOVA), the Tukey-Kramer multiple comparison tests, and the Wilcoxon Signed Rank Sum test, with significance set at P < 0.05. Results: Group C showed higher measurements and significant differences from groups A and B for up to 6 weeks (P < 0.05). There was no difference between groups A and B (P > 0.05). After 6 months, all groups showed significantly higher working lengths from those predetermined, but no statistically significant differences were observed among them (P > 0.05). For all groups, differences from predetermined working lengths were lowest at the 1-week interval. Conclusions: Both alginate and the Apex Putty can be used for determining the working lengths using an apex locator over a longer time period. Our study has shown that ModuPRO Endo™ modules, along with the Apex Putty, are effective tools for teaching working length determination with apex locators in preclinical endodontic training.
  5,005 365 1
CASE REPORTS
Management of adult intralobar pulmonary sequestration: A novel approach
Battal O Aldosary, Yasser M Aljehani, Nawal I Algubaisi, Yahya A. A. Sabaah, Khaled M Alkattan
January-April 2014, 2(1):49-51
DOI:10.4103/1658-631X.128454  
Pulmonary sequestration is a known congenital pulmonary malformation. It has been classified into intralobar and extralobar types. We report a case of a symptomatic adult intralobar pulmonary sequestration which was managed in a rather unconventional approach. Such an approach, arterial embolization, has clearly shown to be safe with good outcome in infants and pediatric population. The patient made a full recovery with good outcome. Such case reports show feasibility and safety of embolization as a less invasive management option for adult pulmonary sequestration.
  4,877 323 2
REVIEW ARTICLES
Variceal bleeding: Current issues
Ibrahim A Al Mofleh
January-April 2014, 2(1):3-11
DOI:10.4103/1658-631X.128397  
Portal hypertension (PHT) is a serious sequel of liver cirrhosis. Eventually, varices develop, grow in size, and bleed. Several diagnostic modalities including transient elastography (TE), capsule endoscopy, CT scanning, and platelets count/spleen diameter ratio (PSR) have recently been introduced. Predictors of bleeding include large varices, red signs, severe liver disease, and hepatic venous pressure gradient (HVPG)12 mmHg. Oral nonselective (NSBB) are recommended for primary prophylaxis in patients with medium-to-large size esophageal varices (EV) that have not bled. Patients with acute variceal bleeding (AVB) should be resuscitated and managed in an intensive care unit. Vasoactive drugs should be started immediately aimed at a better control of bleeding and facilitation of a subsequent endoscopy. Terlipressin controls bleeding and mortality and is considered as the drug of choice. Antibiotic prophylaxis significantly improves survival compared with placebo. Early diagnostic and therapeutic endoscopy in patients with major bleeding enhances control of bleeding, reduces risks of rebleeding and mortality. The use of erythromycin prior to endoscopy clears the stomach, reduces the need for second endoscopy and blood transfusion, and shortens the length of hospital stay. Restricted transfusion strategy prevents portal pressure rise and improves the survival rate. The current recommendation is to treat AVB with a combination of vasoactive agent, EVL, and antibiotics. All patients who survive an episode of AVB should undergo secondary prophylaxis. Transjugular intrahepatic portosystemic shunt (TIPS) using covered stent represents the first-choice rescue treatment. Early TIPS insertion significantly reduces treatment failure, rebleeding, and mortality. Also, insertion of esophageal SX-Ella Danis stent in patients with refractory VB effectively controls bleeding. The data required for this review were obtained mainly through PubMed and Google search.
  4,546 395 -
CASE REPORTS
Unusual presentation of kimura's disease
Amol W Diwan, Gauri P Godbole, Himanshu S Pophale, Suhas R Kulkarni
January-April 2014, 2(1):52-56
DOI:10.4103/1658-631X.128455  
Kimura's disease is a rare form of chronic eosinophilic inflammatory disorder with associated lymphadenopathy in head and neck region and serous cavity effusions and marked predilection for the head and neck with a tendency to present as a discrete, enlarging mass. Although many cases of Kimura's disease with head and neck lymphadenopathy and nephrotic syndrome have been described in the literature, only two cases of Kimura's disease presenting with pleural effusion have been reported recently. There are no reports of Kimura's disease with ascites. We report the case of a 38-year-old nondiabetic, normotensive man who had undergone inguinal node biopsy consistent with Kimura's disease, 8 months before he presented to us. On admission, he had right moderate pleural effusion, but no ascites or any lymph nodal involvement. He developed recurrent pleural effusion and ascites in the ward. Initially he showed good remission with systemic steroids, but later on was refractory to further necessary treatment. He also rapidly developed signs of nephrotic syndrome. In spite of vigorous treatment, patient died of severe hypovolemia, hypoproteinemia, and nephropathy.
  4,507 274 -
ORIGINAL ARTICLES
Lateral sinus thrombosis in children: Case series
Mohamed H Alshehabi, Munahi M Alqahtani, Abdulrahman A Alsanosi, Khalid A Almazrou
January-April 2014, 2(1):30-36
DOI:10.4103/1658-631X.128450  
Lateral sinus thrombosis is rare but potentially fatal condition. The consequences of misdiagnosis of this condition are detrimental. Aims: To review our experience in lateral sinus thrombosis secondary to otogenic disease in pediatric population. Settings and Design: Retrospective study of case series treated in two teaching hospitals over five years. Materials and Methods: Clinically and radiologically diagnosed cases of lateral sinus thrombosis were identified through database search. Results: Lateral sinus thrombosis was the result of chronic suppurative otitis media in 7 cases, with 3 patients (42.85%) having cholesteatoma. There were no associated intracranial complications in any of the patients. Two patients (28.57%) underwent medical treatment, and 5 patients (71.43%) had surgical treatment. Aggressive and early surgical intervention treatment was initiated according to evaluation of preoperative findings. The sigmoid sinus was aspirated in three patients. Complete re-canalization or lysis of the thrombus was achieved. Anticoagulant agent was used in 1 patient (14.28%). Six patients (85.82%) presented with the typical lateral sinus thrombosis clinical features, and 1 patient (14.28%) presented with otorrhea solely. Mastoidectomy was undertaken in 5 patients (71.42%) with canal wall up in 2 patients (28.57%) and canal wall down in 2 patients (28.57%). Myringotomy, ventilation tube insertion, and cortical mastoidectomy were done in 1 patient (14.28%). Conclusions: Early and aggressive surgical intervention of lateral sinus thrombosis otogenic complication can minimize mortality, hospitalization period, and length of medical treatment. High index of suspicion is important.
  3,453 226 -
CASE REPORTS
Bilateral congenital absence of the alae nasi with bilateral auricular sinuses in an albinic child
Aliyu Ibrahim
January-April 2014, 2(1):43-45
DOI:10.4103/1658-631X.128452  
The nose forms from the frontal, medial and lateral nasal prominences of the nasal placode and the maxillary processes. Malformation of the nose is variable; it may be unilateral or bilateral and may be complete absence of the nose called arhinia or isolated absence of the alae narsi. Anomalies of the nose may be associated with defects involving structures that originate from the first and second branchial arches but its association with cutaneous pigmentary disorder and anasarca is a rare occurrence. Therefore a case of a three-month-old girl with such combination is reported.
  3,327 294 -
IMAGE QUIZ
Acute lower abdominal pain in a young female patient
Hassan M Al-Bisher, Hassan A Al-Saleem, Ali M Al-Saffar, Bander F Aldhafery, Abdulmohsen A Al-Mulhim
January-April 2014, 2(1):60-62
DOI:10.4103/1658-631X.128458  
  2,880 523 -
CASE REPORTS
Low-grade dorsal spinal cord astrocytoma presented with paraplegia following minor trauma
Bander F Al-Dhafery, Abdullah S Al-Mulhim, Hossain A. A. Alola
January-April 2014, 2(1):46-48
DOI:10.4103/1658-631X.128453  
Although they constitute about one third of spinal cord glial neoplasms, low-grade astrocytomas can present variably. Post-traumatic neurologic dysfunction due to low-grade spinal cord gliomas is an uncommon event. The authors report a case of paraplegia following minor traumatic event in an 18-month-old boy where subsequent imaging was directed to exclude intracranial hemorrhage. Upon further investigations which included spine-computed tomography and magnetic resonance imaging, a hemorrhagic intraspinal neoplasm was discovered and confirmed to be a low-grade astrocytoma. This case illustrates an instance of significant neurological deficit caused by intratumeral hemorrhage and swelling.
  2,872 201 -
EDITORIAL
Chronic Hepatic Disease
Abdulaziz A Al-Quorain
January-April 2014, 2(1):1-1
DOI:10.4103/1658-631X.128393  
  2,503 333 -
TRIBUTE
Tribute to professor Ibrahim Al-Mofleh
Abdulaziz A Al-Quorain
January-April 2014, 2(1):2-2
DOI:10.4103/1658-631X.128395  
  2,276 326 -
LETTER TO THE EDITOR
Coping with stress among health care professions
Yousef A Al-Turki
January-April 2014, 2(1):59-59
DOI:10.4103/1658-631X.128457  
  2,001 202 -
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