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 Table of Contents  
ORIGINAL ARTICLE
Year : 2021  |  Volume : 9  |  Issue : 3  |  Page : 248-253

Knowledge and practice of pediatric providers regarding neonatal cholestasis in the western region of Saudi Arabia


Department of Pediatric Gastroenterology, King Abdullah International Medical Research Center, National Guard Hospital, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia

Date of Submission05-Aug-2020
Date of Decision22-Oct-2020
Date of Acceptance20-Apr-2021
Date of Web Publication21-Aug-2021

Correspondence Address:
Mohammed Hasosah
Department of Pediatric Gastroenterology, King Abdullah International Medical Research Center, National Guard Hospital, King Saud Bin Abdulaziz University for Health Sciences, PO Box: 8202, Jeddah 21482
Saudi Arabia
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DOI: 10.4103/sjmms.sjmms_462_20

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  Abstract 


Background: Early detection of neonatal cholestasis (NC) is important for better clinical outcomes but can be challenging.
Objective: The objective of this study was to evaluate the knowledge and practice styles of pediatric providers (PPs) regarding NC in the western region of Saudi Arabia.
Methods: This cross-sectional, questionnaire study was conducted between November 2019 and February 2020 in three major cities of the western region of Saudi Arabia (namely, Taif, Makkah and Jeddah). PPs included pediatric residents, pediatric specialists, pediatric consultants and family physicians. The questionnaire included 15 items in five subscales (definition, causes, diagnosis and management of NC and knowledge of guidelines).
Results: A total of 488 participants completed the questionnaire. Only 30.2% were aware of the correct definition of NC (P < 0.001). Two-thirds of the respondents did not consider a history of pale stool being important for evaluating NC. The importance of biliary atresia as a serious cause of NC was found to be significantly different between pediatric consultants and other pediatricians (P < 0.001). In cases of prolonged NC, 32.4% of the PPs refer to pediatric gastroenterologist. Only 18.9% of the respondents were aware of liver biopsy being the gold standard investigation of NC. The majority of the respondents (41.8%) used ursodeoxycholic acid as a supportive therapy of NC.
Conclusions: This study found a significant deficit in the knowledge and practice styles of PPs in the western region of Saudi Arabia. These findings highlight the need for policymakers to develop educational materials for PPs to increase their knowledge of NC.

Keywords: Biliary atresia, knowledge and practice, neonatal cholestasis, pediatricians, prolonged jaundice, Saudi Arabia


How to cite this article:
Hasosah M. Knowledge and practice of pediatric providers regarding neonatal cholestasis in the western region of Saudi Arabia. Saudi J Med Med Sci 2021;9:248-53

How to cite this URL:
Hasosah M. Knowledge and practice of pediatric providers regarding neonatal cholestasis in the western region of Saudi Arabia. Saudi J Med Med Sci [serial online] 2021 [cited 2021 Dec 7];9:248-53. Available from: https://www.sjmms.net/text.asp?2021/9/3/248/324242




  Introduction Top


Neonatal jaundice is common in the first 3 days after birth, but prolonged jaundice, described as a 14-day jaundice, needs diligent evaluation to differentiate between unconjugated hyperbilirubinemia, which is typically mild, and the pathologically related hyperbilirubinemia.[1],[2] According to the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) guidelines, cholestasis is defined as reduction in the bile formation or its flow that results in retention of biliary substances within the liver normally excreted into bile and destined for elimination into the intestinal lumen. A diagnosis of cholestasis can be made with serum evaluations, wherein elevation of serum conjugated (or direct) bilirubin and bile acids are clear indications of hepatobiliary dysfunction.[3],[4]

Identifying and managing neonatal cholestasis (NC) can be challenging, as the patient may initially appear well and gain weight despite cholestasis.[5] To compound this issue, skill deficits have been noted in pediatric providers' (PPs) diagnosis of cholestasis.[6] However, early detection of NC is important, as it may impact the clinical outcome. According to Benchimol et al.,[7] a standardized NC screening could help in the early detection, and thus direct bilirubin rates should be tested in any individual appearing jaundiced and that pediatric hepatologist should automatically be consulted if cholestasis is detected.

Saudi Arabia has a population of about 34 million, of which about 8% are aged 0–4 years,[8] indicating a high birth rate. Therefore, it is important that PPs in Saudi Arabia are familiar with the evaluation of NC for the early diagnosis and timely management. However, no study from Saudi Arabia or the Middle East has assessed the knowledge and practice patterns of PPs toward NC. To fill this gap, this study was conducted with the primary objective of evaluating the knowledge and practice of PPs from Saudi Arabia regarding NC.


  Methods Top


Study design and participants

This cross-sectional, questionnaire study was conducted between November 2019 and February 2020 in three major cities of the western region of Saudi Arabia (namely, Taif, Makkah and Jeddah) and targeted all PPs registered with Saudi Commission for Health Specialties, Saudi Pediatric Association and the Ministry of Health. The research was approved by the Ethics Committee of King Abdullah International Medical Research Center, Jeddah, Saudi Arabia.

The study defines PPs as physicians or pediatricians involved in teaching pediatric medicine or its research or being involved in their clinical care. PPs includes pediatric interns, pediatric residents, pediatric specialists (registrars), pediatric consultants or family physicians; the current study only considered those involved in neonatal care (i.e., aged <28 days). Based on this, 2478 PPs were found to be eligible. A minimum sample size of 333 was calculated through the Raosoft sample size calculator website. However, to attain a more statistically significant representation of the study population, the author chose a random sample of 650 participants after stratifying for gender and profession.

Data collection tool and procedure

The questionnaire was developed using the cholestatic jaundice guidelines published by ESPGHAN/NASPGHAN and the American Academy of Pediatrics (AAP).[3],[4] Its accuracy and functionality were checked by two pediatric gastroenterologists with 5 years of experience, and it was also updated based on the responses of a pilot test conducted on a group of 10 pediatric gastroenterologists (Cronbach's alpha = 0.8). The estimated time for completing the questionnaire was 10 min.

The questionnaire included 15 items in five subscales: Practice and demographics characteristics (four items); causes and definition of cholestasis (five items); cholestasis diagnosis and management (four items); knowledge level regarding the recently published guideline on cholestatic jaundice by ESPGHAN/NASPGHAN (one item); and source of cholestasis-related information (one item). All items were multiple-choice questions, including some using a Likert-like scale (sometimes, most of the time, all of the time, seldom and never).

The data were collected through face-to-face interviews in the majority of cases, with most being conducted at the institutions of the PPs. These were carried out by medical interns who had volunteered for this study and undergone a briefing for the same. In case of unavailability, participants were contacted with the questionnaire through E-mail. The PPs were from Jeddah (two university hospitals, two privates hospitals and five governmental hospitals), Makkah (two private hospitals and three governmental hospitals) and Taif (one governmental hospital and one private hospital). A cover letter was attached with the questionnaire providing a short description of the study and stating that all data obtained would be strictly confidential, anonymity would be maintained, no identifying details would be collected or recorded, and that participation was voluntary. No monetary or nonmonetary benefits were provided to the respondents. Response to the survey was considered as consent for participation, and the same was stated at the end of the questionnaire.

Statistical methods

Data were manually entered in Microsoft Excel and all entries were later cross verified. Data were analyzed using the SPSS software for Windows (version 20.0; IBM Corp., Armonk, NY, USA). The results are presented as percentages, and Person's Chi-square test was used to determine and compare the categorical variables between the groups. P < 0.05 was considered significant.


  Results Top


Demographics

Of the 650 PPs approached for participation in this study, 526 were for face-to-face interviews and 124 received the questionnaire through e-mail. A total of 522 responses were received, but 18 were excluded due to incomplete or missing data, and another 16 were excluded because they were pediatric gastroenterologists, and their inclusion would likely positively skew the data. Therefore, responses from 488 participants (75% response rate) are considered for all further evaluations.

The majority of the respondents were male (n = 268; 55%) and aged 31–40 years (49%). In terms of profession, 46% were pediatric residents, 16% were pediatric consultants and 14% were family physicians [Table 1]
Table 1: Demographic characteristics of the respondents

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.

Definition, causes, diagnosis and management of neonatal cholestasis

Significantly few respondents were aware of the correct definition of NC (n = 138, 28%; P < 0.001). Of these, 53%, 18% and 16% were pediatric residents, consultants and specialists, respectively; 69% were from government hospitals and 27% were from private hospitals. Similarly, significantly few participants were aware of cholestasis workup for jaundice of >2 weeks (25.4%) and a history of pale stool (28.1%) [Table 2]
Table 2: Correlation between responders' status and definition of cholestasis

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.

In terms of diagnosis, only 18.9% reported that biliary atresia should be first ruled out, with significant differences between pediatric consultants and other PPs (P < 0.001). Further, only 92 respondents (18.9%) were aware of liver biopsy being the gold standard investigation for NC. In cases of prolonged cholestasis, 28.3% referred the cases to pediatric gastroenterologists, with most referrals by pediatric consultants and fewest by interns (P < 0.001). Pediatric consultants and pediatric residents preferred ursodeoxycholic acid as the supportive therapy more often than other PPs, but the difference was not statically significant (P = 0.06) [Table 3]. The second most used/preferred supportive therapy after ursodeoxycholic acid was fat-soluble vitamins
Table 3: Correct responses regarding selected aspects of the diagnosis and management of neonatal cholestasis

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.

In terms of management of prolonged NC, 32.4% of PPs evaluate the patient at a clinic every 2 months, 28.3% refer to pediatric gastroenterologist, 24.2% refer to pediatric surgeons and 15% seek hereditary cholestasis testing [Figure 1]. Regarding the guidelines' awareness and knowledge, 37% had very limited and 11% had no awareness of the NASPGHAN/ESPGHAN guidelines for the evaluation of NC [Table 4]. In terms of source of information, 51.2% of the respondents obtained information from medical journals, 37.9% from conferences, 3.6% from newsletters, 4.5% from the Internet and 2.8% from pharmaceutical company–sponsored symposia
Figure 1: Responders' status and strategies for the management of prolonged neonatal cholestasis

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Table 4: Awareness of cholestatic guidelines

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.


  Discussion Top


According to the NASPGHAN/ESPGHAN guidelines, elevated direct/conjugated bilirubin levels >1.0 mg/dL (17 mmol/L), irrespective of the total bilirubin, warrant the evaluation for NC.[4] According to AAP, direct bilirubin >20% of total bilirubin (>5 mg/dL) is defined as conjugated hyperbilirubinemia, and this a biomarker of NC.[3] The latter reference range was used in our study and only 28.3% of PPs were found to be aware of the same. Similarly, Christakis et al.[9] found the AAP's clinical practice guideline was not considered very helpful by most pediatricians and practitioners, which appears to be the case in this study as well.

Surprisingly, about two-thirds of the respondents of this study were unaware of pale stool color being an important history screening for evaluating NC. Menz et al.[6] concluded that 28.5% of PPs were uncomfortable in determining if the stool was pale, thereby highlighting the importance of increasing awareness regarding the use of guidelines. They also demonstrated that there was a gap in knowledge regarding biliary atresia and one-third of PPs in that study were not aware at what point biliary atresia was detected. In our study, 18.9% of PPs reported that biliary atresia should first be ruled out in NC. Lack of awareness is problematic, as it minimizes the sense of urgency, and thus may contribute to complications in the treatment of biliary atresia. Therefore, there is a need to raise awareness regarding screening for NC in Saudi Arabia for earlier diagnosis.

The Italian Guidelines for NC Management recommends the use of biochemical tests for investigating all cases of NC.[10] However, despite advances in lesser invasive diagnostic tools, liver biopsies remain the gold standard.[11] Surprisingly, in our study, only about 19% of the respondents were aware of liver biopsy being the most definitive investigation of NC, highlighting the insufficiency in the PPs of the study. The role of liver biopsy in the diagnosis of biliary atresia and some metabolic liver diseases is critical in the assessment of NC. However, liver biopsy has complications such as abdominal pain, perforation of gall bladder, bile peritonitis, hemobilia and hemothorax.[10]

In a study from the United States, Petrova et al.[12] found that pediatricians initiated the phototherapy treatment at serum bilirubin levels lower that that recommended by AAP. These and our study findings highlight the general lack of understanding of NC among pediatricians. Ursodeoxycholic acid is an epimer of chenodeoxycholic acid that is used as a choleretic and it changes the composition of bile. The mechanism of its action includes the protection of cholangiocytes against cytotoxicity of hydrophobic bile acids, stimulation of hepatobiliary secretion and protection of hepatocytes against bile acid-induced apoptosis.[10] In our study, only about 42% of the respondents used ursodeoxycholic acid as a supportive treatment of cholestasis, highlighting the need for educating PPs regarding the preferred supportive treatment.

The management strategy of prolonged NC varied, with the majority (32.4%) of the participants reported evaluating the patients every 2 months, followed by about 28% referring such cases to pediatric gastroenterologists. Similarly, Palermo et al.[13] had also found variance in the management of prolonged NC. There is a need for standardization regarding management owing to its criticality, as it could inadvertently result in delays in the diagnosis of treatable diseases such as hypothyroidism, tyrosinemia and biliary atresia. In the future, large-scale prospective studies should also assess the role of follow-up of NC in pediatric clinical practice.

Surprisingly, about 24% of the participants in the current study reported referring cases of prolonged NC to pediatric surgeons. The author believes that such patients should mainly be referred to pediatric gastroenterologists/hepatologists rather than to pediatric surgeons. Much of the management can be provided through a co-care model between the pediatricians and the pediatric gastroenterologist. Pediatric surgeons will have a very low threshold for surgical intervention, and this may not always be the right strategy. Recent procedures continue to minimize the resources for early detection and diversion without the overhaul of the treatment programs.[10]

In a study by Gartner et al.,[14] where 443 pediatricians and 444 neonatologists were surveyed to determine their practice patterns in neonatal hyperbilirubinemia, the opinion regarding the AAP guideline to treat neonatal jaundice widely varied. The role for genetic tests is becoming increasingly affordable and relevant in the diagnosis of genetic disorders such as progressive familial intrahepatic cholestasis, galactosemia and inborn errors of bile acid metabolism. Whole-exome sequencing or whole-genome sequencing is an effective and noninvasive diagnostic tool for NC.[15]

This study found that respondents in the studied region of Saudi Arabia have poor adherence to guidelines such as NASPGHAN and ESPGHAN guidelines, which may also be expected given that these guidelines provide recommendations to highly specialized pediatric gastroenterologists. The results of previous studies[6],[9] and our study collectively show the broad differences in diagnostic and knowledge and therapeutic techniques regarding NC among PPs, indicating the need for greater education to promote evidence-based practice through curriculum modifications, improving the standards of continuing medical education programs, facilitating resources, etc., to overcome such challenges.

A key strength of this study is the large sample size and its representativeness of the studied region. However, further research is required from other regions of Saudi Arabia to provide a national representation of this topic. A limitation of this study is that there is likeliness of response bias – only PPs with interest in NC may have been more likely to have responded, and thus is it possible that knowledge of NC may be even lower than that being reported in this study. Another limitation is that the years of experience and academic credentials (such as fellowships, additional certifications, etc.,) were not collected, which may have been confounding factors in the percentage of correct responses.


  Conclusions Top


This study found significant differences between PPs in terms of practice and knowledge regarding the definition, diagnosis and management of NC. The identification of these gaps may be helpful for policy-makers to produce targeted instructional resources on NC for PPs.

Ethical considerations

The Ethics Committee of King Abdullah International Medical Research Center, Jeddah, Saudi Arabia, provided approval for this study (Reference No. RJ20/029/J; Date: March 12, 2020). The study was conducted in line with the guidelines of the Declaration of Helsinki, 2013. Agreeing or responding to the survey was considered as consent for participation.

Peer review

This article was peer-reviewed by four independent and anonymous reviewers.

Acknowledgment

The author thanks all the PPs for participating in the survey. The author would like to sincerely thank Dr. Alaa Iskandani, Dr. Ali Zidan, Dr. Mohammed Qahtani, Dr. Fahad Zahrani (Pediatric Department, National Guard Hospital, King Saud bin Abdulaziz University for Health Sciences, Jeddah, KSA) who approached the participants and conducted the face-to-face interviews. Special thanks to Dr. Muhammad A Khan (College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, KSA) who analyzed the results.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
McKiernan PJ. The infant with prolonged jaundice: Investigation and management. Curr Paediatr 2001;11:83-9.  Back to cited text no. 1
    
2.
De Bruyne R, Van Biervliet S, Vande Velde S, Van Winckel M. Clinical practice: Neonatal cholestasis. Eur J Pediatr 2011;170:279-84.  Back to cited text no. 2
    
3.
American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 2004;114:297-316.  Back to cited text no. 3
    
4.
Fawaz R, Baumann U, Ekong U, Fischler B, Hadzic N, Mack CL, et al. Guideline for the evaluation of cholestatic jaundice in Infants: Joint recommendations of the North American, and Nutrition and the European Society for Pediatric Gastroenterology, Society for Pediatric Gastroenterology, Hepatology Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 2017;64:154-68.  Back to cited text no. 4
    
5.
Mowat AP, Davidson LL, Dick MC. Earlier identification of biliary atresia and hepatobiliary disease: Selective screening in the third week of life. Arch Dis Child 1995;72:90-2.  Back to cited text no. 5
    
6.
Menz TJ, Herzlinger M, Ross A, Zonfrillo MR. Knowledge, attitudes, and behaviors of pediatric primary care providers on management of cholestasis. Glob Pediatr Health 2019;6:2333794X19829757.  Back to cited text no. 6
    
7.
Benchimol EI, Walsh CM, Ling SC. Early diagnosis of neonatal cholestatic jaundice: Test at 2 weeks. Can Fam Physician 2009;55:1184-92.  Back to cited text no. 7
    
8.
Stats.gov.sa. Saudi Arabia: General Authority for Statistics in the Kingdom of Saudi Arabia; c2019. Available from: https://www.stats.gov.sa/sites/default/files/population_by_age_groups_and_gender_en.pdf. [Last accessed on 2021 Jan 10].  Back to cited text no. 8
    
9.
Christakis DA, Rivara FP. Pediatricians' awareness of and attitudes about four clinical practice guidelines. Pediatrics 1998;101:825-30.  Back to cited text no. 9
    
10.
Palermo JJ, Joerger S, Turmelle Y, Putnam P, Garbutt J. Neonatal cholestasis: Opportunities to increase early detection. Acad Pediatr 2012;12:283-7.  Back to cited text no. 10
    
11.
Rockey DC, Caldwell SH, Goodman ZD, Nelson RC, Smith AD; American Association for the Study of Liver Diseases. Liver biopsy. Hepatology 2009;49:1017-44.  Back to cited text no. 11
    
12.
Dani C, Pratesi S, Raimondi F, Romagnoli C; Task Force for Hyperbilirubinemia of the Italian Society of Neonatology. Italian guidelines for the management and treatment of neonatal cholestasis. Ital J Pediatr 2015;41:69.  Back to cited text no. 12
    
13.
Petrova A, Mehta R, Birchwood G, Ostfeld B, Hegyi T. Management of neonatal hyperbilirubinemia: Pediatricians' practices and educational needs. BMC Pediatr 2006;6:6.  Back to cited text no. 13
    
14.
Gartner LM, Herrarias CT, Sebring RH. Practice patterns in neonatal hyperbilirubinemia. Pediatrics 1998;101:25-31.  Back to cited text no. 14
    
15.
Herbst SM, Schirmer S, Posovszky C, Jochum F, Rodi T, Schrchoeder JA, et al. Taking the next step forward - diagnosing inherited infantile cholestatic disorders with next generation sequencing. Mol Cell Probes 2015;29:291-8.  Back to cited text no. 15
    


    Figures

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    Tables

  [Table 1], [Table 2], [Table 3], [Table 4]



 

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