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BRIEF REPORT
Year : 2021  |  Volume : 9  |  Issue : 2  |  Page : 175-177

“Thrombectomy and Back:” A novel approach for treating patients with large vessel occlusion in the Eastern Province of Saudi Arabia


1 Department of Neurosurgery and Critical Care Medicine, Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Al-Khobar, Saudi Arabia; Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
2 Department of Neurology, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Al-Khobar, Saudi Arabia
3 Department of Neurosciences, King Fahad Specialist Hospital, Dammam, Saudi Arabia
4 Department of Neurosurgery and Critical Care Medicine, Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Al-Khobar, Saudi Arabia

Date of Submission20-Apr-2020
Date of Acceptance05-Apr-2012
Date of Web Publication29-Apr-2021

Correspondence Address:
Hosam Al-Jehani
Department of Neurosurgery and Critical Care Medicine, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Al-Khobar

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DOI: 10.4103/sjmms.sjmms_119_20

PMID: 34084109

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  Abstract 


Background: Timely access to comprehensive stroke centers for patients suffering from acute ischemic stroke due to large vessel occlusion (LVO) remains a commonly encountered obstacle worldwide, especially in areas with no comprehensive stroke or thrombectomy-capable stroke centers.
Objective: To present our novel experience with a “thrombectomy-and-back” model implemented in the Eastern Province of Saudi Arabia.
Methods: King Fahd Hospital of the University (KFHU), a 600-bed hospital located in Al Khobar with an open-access emergency department, was designated as a comprehensive stroke center in the Eastern Province. “Thrombectomy-and-back” was designed such that the neurologist in the referring hospital directly communicates with the attending neurovascular team at KFHU for their anticipation of the case, and subsequently confirms LVO presence through urgent acquisition of a CT and a CT angiogram. Once LVO was confirmed, the patients were timely transferred to KFHU for mechanical thrombectomy. Upon procedure completion, the patients returned to the referring hospital with the same medical and EMS team. The safety of transfer and peri-procedural complications were analyzed.
Results: From December 2017 to December 2019, 20 thrombectomy-and-back codes were activated, of which 10 were deactivated on negative LVO and 10 remained activated. Of these 10 patients, 2 required admission to our hospital's Neuro-ICU: one was because the middle cerebral artery reoccluded during the procedure and the other was due to hemodynamic instability upon arrival; this first patient passed away 2 months later due to the complications of the malignant left middle cerebral artery stroke.
Conclusions: The novel Thrombectomy-and-Back model in the Eastern Province of Saudi Arabia has proved to be a safe and efficient approach for patients presenting with LVO to receive timely interventional therapy and minimizing futile transfers.

Keywords: Acute ischemic stroke, occlusion, tele-stroke, thrombectomy


How to cite this article:
Al-Jehani H, AlHamid MA, Hudhiah K, Al-Bakr A, Bunayan R, AlAbbas F. “Thrombectomy and Back:” A novel approach for treating patients with large vessel occlusion in the Eastern Province of Saudi Arabia. Saudi J Med Med Sci 2021;9:175-7

How to cite this URL:
Al-Jehani H, AlHamid MA, Hudhiah K, Al-Bakr A, Bunayan R, AlAbbas F. “Thrombectomy and Back:” A novel approach for treating patients with large vessel occlusion in the Eastern Province of Saudi Arabia. Saudi J Med Med Sci [serial online] 2021 [cited 2021 Sep 18];9:175-7. Available from: https://www.sjmms.net/text.asp?2021/9/2/175/315132




  Introduction Top


Ischemic stroke due to large vessel occlusion (LVO) has serious consequences for patients if left untreated. There is a growing body of literature with a strong level of evidence demonstrating the benefits of mechanical thrombectomy (MT) for patients with LVOs.[1],[2] This is evident in patients treated within 6 hours of last seen well (LSW) and for a carefully selected few within 24 hours of LSW.

Due to geographical or logistical restrains, some acute ischemic stroke (AIS) patients might not have access to a dedicated interventional neuroradiology (INR) services at the receiving hospital. This is compounded by the limited number of neuro-interventionists available to cover a large catchment area. The classic transfer model of patient would risk burdening any thrombectomy-capable center with the anticipated long-term recovery period of stroke patients who suffer from LVOs. This raises the need to provide patients with timely transfer to Comprehensive Stroke centers with 24/7 INR services with a pathway that ensures their safe return to their receiving hospital.[3],[4]

We aim to describe our unique experience as the first comprehensive stroke center in Saudi Arabia to implement the “Thrombectomy and Back” (T&B) protocol, which provides acute MT for patients presenting with LVOs from different hospitals throughout the Eastern Province of Saudi Arabia who were eligible for MT or urgent endovascular thrombectomy and transferring them back to the referring hospitals after the procedure.


  Methods Top


King Fahd Hospital of the University (KFHU) in AlKhobar, Saudi Arabia, is a tertiary care center that has an open-access Emergency Department. KFHU offers comprehensive stroke services to the region and has dedicated Neurovascular and Neuro-ICU services, with an average of 40 MTs performed annually. The proposed model was designed to allow patients in primary stroke centers, who do not have access to the time-sensitive MT, to be transferred to comprehensive stroke/thrombectomy-capable stroke centers, where they would receive timely treatment.[5] This is done by direct communication between the treating neurologists of the regional primary stroke center and the INR team at KFHU. To reduce the possibility of “futile transfers,” the model was designed to provide the acquisition of an urgent CT/CT angiogram in the primary stroke center to document the LVO prior to the initiation of the transfer. This would not interfere with the decisions of IV thrombolysis for eligible patients, conforming to the drip and ship model.[6]

In this model, the neurologist in the referring hospital activated T&B code, through direct communication with any INR team members' cell phone as soon as they identify patients coming with acute neurological deficits, which could be attributed to an LVO before obtaining CTA. If the CTA was negative for an LVO, Code “T&B” would be deactivated. For those patients with LVO on CTA, the transfer was initiated, and the representative images were electronically shared. Upon arrival at KFHU, the patients had a brief period of registration in the emergency room, after which they were shifted to the angio-suite for thrombectomy. The transferring medical and EMS team remain in KFHU until completion of MT. If the patients transfer was delayed or if their NIH Stroke Scale/Score increased or clinical condition worsened during the transfer, CT/CTA were repeated along with CT perfusion in our hospital, to allow for proper assessment of tissue preservation to ensure eligibility for MT. Once the thrombectomy procedure is completed, the patient returns in the same ambulance to the referring hospital. The model proposes that if the patient deteriorates after MT, they are to be admitted under our Neuro-ICU service for further management.

We analyzed the safety and feasibility of our T&B model through patient transfer and peri-procedural complications.


  Results Top


From December 2017 to December 2019, a total of 20 Code T&B were activated from three hospitals. Of these, 10 patients did not have an LVO in their CTA and code T&B was deactivated, while 10 remained activated and were transferred to our hospital for MT.

Of the 10 patients for T&B, two required admission to our hospital's Neuro-ICU [Table 1]. In the first case, the middle cerebral artery (MCA) reoccluded during the procedure, so we chose to keep patient in anticipation. The patient developed a malignant Left MCA infarction and subsequently passed away 2 months later. The second patient was found to have a right CCA dissection for which an acute treatment was deferred. During the procedure, the patient was found to be hemodynamically unstable precluding her transfer back to the referring hospital on the same day. She was admitted to our ICU and was transferred back 3 days later after she was stabilized. The T&B model prevented 50% futile transfers and mitigated the cost of admission of 8 AIS patients, all of which received their time-sensitive intervention in accordance to the standards of care.
Table 1: Patient demographics and details of thrombectomy and back

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  Conclusions Top


The Thrombectomy and Back proved to be a novel model of care for stroke patients suffering from LVOs that require urgent EVT in the eastern province of Saudi Arabia. This model can be duplicated in areas with similar logistical constrains.

Ethical considerations

This study was retrospectively approved by the Institutional Review Board at Imam Abdulrahman Bin Faisal University (Reference No. IRB-2020-01-254), Dammam, Saudi Arabia, on September 06, 2020. Informed consent was not sought because the study retrospectively reports de-identified information focusing on logistics of care rather than individual patient outcome.[7]

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Adeoye O, Nyström KV, Yavagal DR, Luciano J, Nogueira RG, Zorowitz RD, et al. Recommendations for the establishment of stroke systems of care: A 2019 update a policy statement from the American Stroke Association. Stroke 2019;50:e187-210.  Back to cited text no. 1
    
2.
Malhotra K, Gornbein J, Saver JL. Ischemic strokes due to large-vessel occlusions contribute disproportionately to stroke-related dependence and death: A review. Front Neurol 2017;8:651.  Back to cited text no. 2
    
3.
Brandler ES, Baksh N. Emergency management of stroke in the era of mechanical thrombectomy. Clin Exp Emerg Med 2019;6:273-87.  Back to cited text no. 3
    
4.
Jayaraman MV, Iqbal A, Silver B, Siket MS, Amedee C, McTaggart RA, et al. Developing a statewide protocol to ensure patients with suspected emergent large vessel occlusion are directly triaged in the field to a comprehensive stroke center: How we did it. J Neurointerv Surg 2017;9:330-2.  Back to cited text no. 4
    
5.
Noorian AR, Sanossian N, Shkirkova K, Liebeskind DS, Eckstein M, Stratton SJ, et al. Los Angeles motor scale to identify large vessel occlusion: Prehospital validation and comparison with other screens. Stroke 2018;49:565-72.  Back to cited text no. 5
    
6.
Ismail M, Armoiry X, Tau N, Zhu F, Sadeh-Gonik U, Piotin M, et al. Mothership versus drip and ship for thrombectomy in patients who had an acute stroke: A systematic review and meta-analysis. J Neurointerv Surg 2019;11:14-9.  Back to cited text no. 6
    
7.
Rebers S, Aaronson NK, van Leeuwen FE, Schmidt MK. Exceptions to the rule of informed consent for research with an intervention. BMC Med Ethics 2016;17:9.  Back to cited text no. 7
    



 
 
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