|Year : 2016 | Volume
| Issue : 1 | Page : 38-41
Sialolipoma of the superficial lobe of the parotid gland: A case report and literature review
Ahmed Eldamati1, Rabia Niaz1, Shumaila Tanveer1, Hazem Zakaria1, Nasser AlJazzan2, Tarek El-Sharkawy3, Bander AlDhafery4, Abdulmohsen A Al-Mulhim1
1 Department of Surgery, King Fahd Hospital of the University, College of Medicine, University of Dammam, Dammam, Saudi Arabia
2 Department of ENT, King Fahd Hospital of the University, College of Medicine, University of Dammam, Dammam, Saudi Arabia
3 Department of Pathology, King Fahd Hospital of the University, College of Medicine, University of Dammam, Dammam, Saudi Arabia
4 Department of Radiology, King Fahd Hospital of the University, College of Medicine, University of Dammam, Dammam, Saudi Arabia
|Date of Web Publication||2-Dec-2015|
Abdulmohsen A Al-Mulhim
P.O. Box: 1917, Al-Khobar 31952
Sialolipoma of the parotid gland is very rare. We report a case of a 38-year-old woman who presented with a painless, slowly growing, mobile lump of the parotid gland. Computed tomography revealed lipoma of the superficial lobe of the parotid gland. Superficial parotidectomy was performed with uneventful postoperative course. The histology showed sialolipoma. Review of the 25 reported cases (including our case) of parotid sialolipoma shows that this tumor is more common in the fifth decade of life, on the left side and the superficial lobe. It has a slight preference for men. Its clinical presentation mimics the standard (pure) parotid lipoma and other more common benign parotid tumors particularly pleomorphic adenoma and Warthin's tumor. Surgical excision is curative with minor complications and small recurrence rate. Histological examination is necessary to establish the diagnosis and to exclude malignancy.
ملخص البحث :
يعتبر ورم الغدة النكافية من الأورام النادرة. يعرض الباحثون حالة لسيدة في الثامنة والثلاثين من عمرها تعاني من تضخم بطئ النمو وغير مؤلم في الغدة النكافية. وضحت الأشعة المقطعية ورم شحمي في الفص السطحي للغدة النكافية وقد تم استئصاله. أظهر الفحص المجهري أنه من نوع ورم الغدة النكافية الشحمي. بينت الدراسات السابقة أن هذا النوع من الأورام يكثر في العقد الخامس من العمر وفي الجهة اليسرى ويكثر لدى الذكور. يعالج هذا النوع من الأورام بالاستئصال. ويعتبر الفحص النسيجي ضروريا للوصول للتشخيص النهائي لاستبعاد الحالات السرطانية.
Keywords: Parotid, sialolipoma, superficial parotidectomy
|How to cite this article:|
Eldamati A, Niaz R, Tanveer S, Zakaria H, AlJazzan N, El-Sharkawy T, AlDhafery B, Al-Mulhim AA. Sialolipoma of the superficial lobe of the parotid gland: A case report and literature review. Saudi J Med Med Sci 2016;4:38-41
|How to cite this URL:|
Eldamati A, Niaz R, Tanveer S, Zakaria H, AlJazzan N, El-Sharkawy T, AlDhafery B, Al-Mulhim AA. Sialolipoma of the superficial lobe of the parotid gland: A case report and literature review. Saudi J Med Med Sci [serial online] 2016 [cited 2021 Mar 4];4:38-41. Available from: https://www.sjmms.net/text.asp?2016/4/1/38/170893
| Introduction|| |
Lipomatous tumors of the parotid gland are rare, accounting for 0.1-4.4% of all parotid tumors. , In addition to the standard (pure) lipoma of the parotid gland, other histological subtypes have been described, e.g., angiolipoma, fibrolipoma, sialolipoma, and liposarcoma.  Nagao et al. first coined the term "sialolipoma" in 2001.  This tumor is characterized by "a well-circumscribed mass composed of glandular tissue and mature adipose elements".  At present, 51 cases of sialolipoma have been reported in the world literature; 25 in the parotid gland, ,,,,,,,,,,,,,,, six in the submandibular gland, , and the rest involved the minor salivary glands. ,, We add one more case of parotid sialolipoma and review the literature.
| Case report|| |
A 38-year-old healthy woman presented with a 3-month history of painless slow-growing lump on the left side of the face. Her past medical history was unremarkable, and she denied any history of trauma or infection of the face. The swelling was 2 cm × 3 cm, nontender, mobile, soft and well-demarcated. The facial nerve was intact, and there were no other salivary swellings or cervical lymphadenopathy. The clinical impression was left parotid swelling, most likely to be a pleomorphic adenoma or Warthin's tumor. On ultrasound, the lesion was 2.0 cm × 1.7 cm, hypoechoic and well-defined at the lateral aspect of the left parotid gland with minimal vascularity suggestive of pleomorphic adenoma. Computed tomography (CT) with intravenous contrast revealed a 2.8 cm × 2.2 cm × 1.9 cm, well-demarcated, macro-lobulated hypodense lesion with no significant contrast enhancement [Figure 1]. The diagnosis was lipoma of the superficial lobe of the left parotid gland. Left superficial parotidectomy with facial nerve dissection and preservation was performed with uneventful postoperative course. The excised tumor was encapsulated, lobulated, tan-brown and measured 4.8 cm × 4.0 cm × 1.2 cm. The histological diagnosis was sialolipoma [Figure 2] and the amount of fat was approximately 90%. The rest of the superficial lobe was normal. The patient remained well 8 months after surgery with no recurrence.
|Figure 1: Contrast-enhanced axial computed tomography scan of upper neck showing 28 mm × 22 mm well-demarcated, encapsulated lipoma of the superfi cial lobe of the left parotid gland (arrow). The right parotid gland is normal|
Click here to view
| Discussion|| |
Parotid lipomatous tumors are classified into several histological variants. The standard (true) lipoma is the most common type. ,, Sialolipoma, on the other hand, is very rare, accounting for only 0.3% of all salivary gland tumors.  It is more frequently seen in the parotid gland. ,,
All the cases of parotid sialolipoma are written in English, ,,,,,,,,,,,,,, except one in German.  These cases (including our case) are summarized in [Table 1], except the case reported by Starkman et al. because of insufficient data in the original paper.  Although parotid sialolipoma can affect children and adults, 20 (80%) patients in the literature were adults. Most of the adult patients were in the fifth decade of life (45%) with a mean age of 47 years (range: 18-74 years). The tumor has a small male preference; 52% of the patients were men. Data on duration of symptoms was available for 18 patients; the mean duration was 30 months (range: 1.5-132 months). Information on laterality of the tumor was available for 24 patients; 16 (66%) lumps involved the left side and 8 (33%) the right side. The tumor was located in the superficial lobe in 19 patients, in the deep lobe and both lobes in one patient each, and in four patients the location was not specified. The size was variable. The largest tumor was 75 mm in its greatest dimension, while the smallest was 10 mm in diameter. Follow-up data was available for 17 patients. The mean duration of follow-up was 31.2 months (range: 3-93 months). The outcome of surgery was good with minor complications. ,, [Table 1] shows that none of the patients but one had recurrence. 
|Table 1: Summary of cases of sialolipoma of the parotid gland reported between 1976 and 2014|
Click here to view
Parotid sialolipoma usually presents as a painless slowly growing soft mobile well-demarcated lump with intact facial nerve in an otherwise healthy patient. Similar to the pure lipoma, the most likely preoperative diagnosis is a pleomorphic adenoma versus Warthin's tumor. , Routine laboratory tests are not helpful in establishing the diagnosis. Advanced imagings play the major role in the preoperative diagnosis of these lesions [Table 1]. Today, CT and magnetic resonance imaging (MRI) are the cornerstones for establishing the diagnosis. However, these imagings cannot differentiate sialolipoma from a pure lipoma. In our case, once the CT diagnosis of a lipoma was made, other diagnostic tools, such as fine-needle aspiration (FNA) were not utilized. This approach is supported by the literature, which indicates that in most instances FNA is not helpful in the preoperative work-up. ,,, We believe that superficial parotidectomy is the treatment of choice for sialolipomas of the superficial lobe of the parotid. This approach ensures complete excision of the tumor and excludes malignancy. As in other reports, our operative diagnosis was a lipoma. However, it was only during histological examination that the diagnosis of a sialolipoma was made.
Because of its rarity, certain issues remain unanswered. In addition to the classical histological features of sialolipoma described by Nagao et al.,  other features have been highlighted. These include the presence of sebaceous differentiation,  nerve bundles,  oncocytic cells, , duct ectasia, lymphocytic infiltration, , and periductal fibrosis and inflammation.  As with Michaelidis et al.,  the microscopic features in our case included the presence of nerve fibers. However, in contrast to Michaelidis et al.,  we did not encounter any difficulty in the identification of the facial nerve and excision of the tumor. Therefore, more studies are needed to establish the full histological spectrum of sialolipomas. This is important to (1) explain their pathogenesis, clinical behavior and biological features, (2) establish a standard terminology and (3) determine the extent of surgical intervention.
| Conclusion|| |
Lipoma must be included in the differential diagnosis of a painless, slowly growing, mobile, soft lump of the parotid gland. CT and MRI are the cornerstones for establishing the preoperative diagnosis. However, surgical excision and histological examination are necessary to diagnose sialolipoma.
| References|| |
Baker SE, Jensen JL, Correll RW. Lipomas of the parotid gland. Oral Surg Oral Med Oral Pathol 1981;52:167-71.
Nagao T, Sugano I, Ishida Y, Asoh A, Munakata S, Yamazaki K, et al.
Sialolipoma: A report of seven cases of a new variant of salivary gland lipoma. Histopathology 2001;38:30-6.
Starkman SJ, Olsen SM, Lewis JE, Olsen KD, Sabri A. Lipomatous lesions of the parotid gland: Analysis of 70 cases. Laryngoscope 2013;123:651-6.
Walts AE, Perzik SL. Lipomatous lesions of the parotid area. Arch Otolaryngol 1976;102:230-2.
Hornigold R, Morgan PR, Pearce A, Gleeson MJ. Congenital sialolipoma of the parotid gland first reported case and review of the literature. Int J Pediatr Otorhinolaryngol 2005;69:429-34.
Michaelidis IG, Stefanopoulos PK, Sambaziotis D, Zahos MA, Papadimitriou GA. Sialolipoma of the parotid gland. J Craniomaxillofac Surg 2006;34:43-6.
Kadivar M, Shahzadi SZ, Javadi M. Sialolipoma of the parotid gland with diffuse sebaceous differentiation in a female child. Pediatr Dev Pathol 2007;10:138-41.
Bansal B, Ramavat AS, Gupta S, Singh S, Sharma A, Gupta K, et al.
Congenital sialolipoma of parotid gland: A report of rare and recently described entity with review of literature. Pediatr Dev Pathol 2007;10:244-6.
Maiorano E, Capodiferro S, Fanelli B, Calabrese L, Napoli A, Favia G. Hamartomatous angiolipoma of the parotid gland (sialoangiolipoma). Head Neck Pathol 2008;2:36-40.
Fritzsche FR, Bode PK, Stinn B, Huber GF, Noske A. Sialolipoma of the parotid gland. Pathologe 2009;30:478-80.
Dogan S, Can IH, Unlü I, Süngü N, Gönültas MA, Samim EE. Sialolipoma of the parotid gland. J Craniofac Surg 2009;20:847-8.
Kidambi T, Been MJ, Maddalozzo J. Congenital sialolipoma of the parotid gland: Presentation, diagnosis, and management. Am J Otolaryngol 2012;33:279-81.
Qayyum S, Meacham R, Sebelik M, Zafar N. Sialolipoma of the parotid gland: Case report with literature review comparing major and minor salivary gland sialolipomas. J Oral Maxillofac Pathol 2013;17:95-7.
Agaimy A, Ihrler S, Märkl B, Lell M, Zenk J, Hartmann A, et al.
Lipomatous salivary gland tumors: A series of 31 cases spanning their morphologic spectrum with emphasis on sialolipoma and oncocytic lipoadenoma. Am J Surg Pathol 2013;37:128-37.
Khazaeni K, Jafarian AH, Khajehahmadi S, Rahpeyma A, Asadi L. Sialolipoma of salivary glands: Two case reports and review of the literature. Dent Res J (Isfahan) 2013;10:93-7.
Lee PH, Chen JJ, Tsou YA. A recurrent sialolipoma of the parotid gland: A case report. Oncol Lett 2014;7:1981-983.
Ahn D, Park TI, Park J, Heo SJ. Oncocytic sialolipoma of the submandibular gland. Clin Exp Otorhinolaryngol 2014;7:149-52.
Ponniah I, Lavanya N, SureshKumar P. Island of salivary gland in adipose tissue: A report of three cases. J Oral Pathol Med 2007;36:558-62.
Binmadi NO, Chaisuparat R, Levy BA, Nikitakis NG. Sialolipoma of the lower lip: Case report and literature review. Open Dent J 2012;6:208-11.
[Figure 1], [Figure 2]
|This article has been cited by|
||Sialolipoma in the oropharyngeal region of minor salivary gland origin: A case report
| ||Kenzo Ohara,Takeshi Kanaya,Yasuaki Harabuchi |
| ||Otolaryngology Case Reports. 2020; : 100250 |
|[Pubmed] | [DOI]|
||Sialolipoma of Parotid Gland: a Lesser Known Entity
| ||Sudeep Khera,Poonam Elhence,Neha Bagga,Pavan Garg,Ramkaran Choudhary |
| ||Indian Journal of Surgery. 2020; 82(1): 90 |
|[Pubmed] | [DOI]|
||Oncocytic Sialolipoma of Parotid Gland: Case Report and Literature Review
| ||Komkrit Ruangritchankul,Steve Connor,Richard Oakley |
| ||Head and Neck Pathology. 2018; |
|[Pubmed] | [DOI]|
||Sialolipoma of the parotid salivary gland in two dogs
| ||Verónica Rodiño Tilve,Marlene Finck,Joshua DG Leach,Michael J Macfarlane |
| ||Veterinary Record Case Reports. 2017; 5(2): e000376 |
|[Pubmed] | [DOI]|