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Year : 2013  |  Volume : 1  |  Issue : 2  |  Page : 118

Should we screen diabetic patients for vitamin D deficiency?

Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia

Date of Web Publication25-Dec-2013

Correspondence Address:
Yousef A Al Turki
Department of Family and Community Medicine, King Saud University, College of Medicine, Riyadh
Saudi Arabia
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DOI: 10.4103/1658-631X.123650

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How to cite this article:
Al Turki YA. Should we screen diabetic patients for vitamin D deficiency?. Saudi J Med Med Sci 2013;1:118

How to cite this URL:
Al Turki YA. Should we screen diabetic patients for vitamin D deficiency?. Saudi J Med Med Sci [serial online] 2013 [cited 2021 Mar 1];1:118. Available from: https://www.sjmms.net/text.asp?2013/1/2/118/123650


Vitamin D deficiency predisposes individuals to type 1 and type 2 diabetes, and receptors for its activated form-1α,25-dihydroxyvitamin D 3 have been identified in both beta cells and immune cells. Vitamin D deficiency may, therefore, be involved in the pathogenesis of both forms of diabetes, and a better understanding of the mechanisms involved could lead to the development of preventive strategies. [1],[2] Although the role of vitamin D in helping to regulate blood glucose remains poorly understood, vitamin D status appears to play a role in the development and treatment of diabetes. It is possible that optimal levels of serum vitamin D may be different for people at risk for developing diabetes, those with diabetes, and those without diabetes. Both animal and human studies support the notion that adequate vitamin D supplementation may decrease the incidence of type 1 and possibly also of type 2 diabetes mellitus and may improve the metabolic control in the diabetes state. However, the exact mechanisms are not clear and need further investigation. [3],[4] Another study finding support a mechanistic link between serum vitamin D concentrations, glucose homeostasis, and the evolution of diabetes in a large segment of adult population, and it recommends screening people with elevated A1C levels for vitamin D insufficiency should be considered. [5] So, further experts' opinion and clinical evidence-based medicine need to be discussed more about these debatable important clinical issues, especially regarding vitamin D deficiency among diabetic patients.

  References Top

1.Mathieu C, Gysemans C, Giulietti A, Bouillon R. Vitamin D and diabetes. Diabetologia 2005;48:1247-57.  Back to cited text no. 1
2.Forouhi NG, Luan J, Cooper A, Boucher BJ, Wareham NJ. Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: The Medical Research Council Ely Prospective Study 1990-2000. Diabetes 2008;57:2619-25.  Back to cited text no. 2
3.Martin T, Keith Campbell R. Vitamin D and Diabetes. Diabetes Spectr 2011;24:113-8.  Back to cited text no. 3
4.Schwallenberg G. Vitamin D and diabetes: Improvement of glycemic control with vitamin D 3 repletion. Can Fam Phys 2008;54:864-6.  Back to cited text no. 4
5.Kositsawat J, Gerber BS, Freeman VL, Geraci S. Association of A1C levels with vitamin D status in U.S. adults. Diabetes Care 2010;33:1236-8.  Back to cited text no. 5


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