ORIGINAL ARTICLE
Year : 2018 | Volume
: 6 | Issue : 3 | Page : 137--142
Effect of vitamin D and calcium supplementation in patients with systemic lupus erythematosus
Abdullah G Al-Kushi1, Firas S Azzeh2, Eslam A Header3, Naser A ElSawy4, Haifa H Hijazi2, Abdelelah S Jazar2, Mazen M Ghaith6, Mohammed A Alarjah5
1 Department of Anatomy, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia
2 Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia
3 Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia; Department of Nutrition and Food Science, Faculty of Home Economics, Menoufia University, Shibin Al Kawm, Egypt
4 Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia; Department of Anatomy and Embryology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
5 Department of Pharmaceutical Chemistry, College of Pharmacy, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia
Correspondence Address:
Firas S Azzeh
Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al-Qura University, P.O. Box: 7067, Makkah 21955
Kingdom of Saudi Arabia
Background: Systemic lupus erythematosus is a chronic autoimmune disease that increases the risk of suboptimal vitamin D levels.
Aim: To determine the effects of vitamin D and calcium supplementation on disease activity, related immune markers and bone mineral density in patients with systemic lupus erythematosus.
Subjects and Methods: Eighty-one patients with systemic lupus erythematosus aged 20–70 years were recruited for this interventional study. Participants were enrolled into the following groups: no corticosteroid treatment (n = 21), corticosteroid treatment but without supplementation (n = 30) and corticosteroid treatment along with oral vitamin D and calcium supplementation (n = 30). Disease activity and laboratory parameters of all participants were measured at baseline and at 6 months. Bone mineral density was assessed using standardized dual-energy X-ray absorptiometry.
Results: At baseline, none of the patients had a normal vitamin D status. There were no significant correlations between vitamin D status and the studied immune markers or disease activity values before and after supplementation. After 6 months, patients who received supplementation showed significant (P = 0.002) improvements in bone mineral density. In addition, frequency of osteopenia decreased from 40% to 16.7% and that of osteoporosis decreased from 26.7% to 13.3%.
Conclusion: Vitamin D and calcium supplementation significantly improved the bone mineral density in vitamin D-deficient patients with systemic lupus erythematosus but did not significantly attenuate immune markers or disease activity. Further investigations are recommended with higher doses of vitamin D and longer durations to normalize the vitamin level and, possibly, achieve better disease control.
How to cite this article:
Al-Kushi AG, Azzeh FS, Header EA, ElSawy NA, Hijazi HH, Jazar AS, Ghaith MM, Alarjah MA. Effect of vitamin D and calcium supplementation in patients with systemic lupus erythematosus
.Saudi J Med Med Sci 2018;6:137-142
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How to cite this URL:
Al-Kushi AG, Azzeh FS, Header EA, ElSawy NA, Hijazi HH, Jazar AS, Ghaith MM, Alarjah MA. Effect of vitamin D and calcium supplementation in patients with systemic lupus erythematosus
. Saudi J Med Med Sci [serial online] 2018 [cited 2019 Feb 18 ];6:137-142
Available from: http://www.sjmms.net/article.asp?issn=1658-631X;year=2018;volume=6;issue=3;spage=137;epage=142;aulast=Al-Kushi;type=0 |
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