|Year : 2019 | Volume
| Issue : 3 | Page : 222-225
Natural Killer/T-Cell lymphoma: Saudi Lymphoma Group's clinical practice guidelines for diagnosis, management and follow-up
Ibraheem Motabi1, Musa Alzahrani2, Reyad Dada3, Mubarak Al-Mansour4, Hani Alhashmi5, Magdy Kandil6, Ahmed Sagheir7, Ayman Alhejazi8
1 Department of Adult Hematology and BMT, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, Saudi Arabia
2 Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia
3 Department of Oncology, King Faisal Specialist Hospital and Research Centre, Jeddah; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
4 College of Medicine, King Saud Bin Abdulaziz University for Health Sciences; Adult Medical Oncology, Princess Noorah Oncology Center, King Abdulaziz Medical City, Ministry of National Guard Health Affairs-Western Region, Jeddah, Saudi Arabia
5 Adult Hematology and Stem Cell Transplantation Department, King Fahad Specialist Hospital, Dammam, Saudi Arabia
6 Medical Oncology Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia; Clinical Oncology Department, Cairo University, Giza, Egypt
7 Oncology Institute, John Hopkins Aramco Healthcare, Dhahran, Saudi Arabia
8 Department of Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs-Central Region, Riyadh, Saudi Arabia
|Date of Submission||25-Mar-2019|
|Date of Decision||06-May-2019|
|Date of Acceptance||24-Jul-2019|
|Date of Web Publication||28-Aug-2019|
Dr. Mubarak Al-Mansour
Adult Medical Oncology, Princess Noorah Oncology Center, King Abdulaziz Medical City, Ministry of National Guard Health Affairs-Western Region, PO Box 9515, Jeddah 21423
|How to cite this article:|
Motabi I, Alzahrani M, Dada R, Al-Mansour M, Alhashmi H, Kandil M, Sagheir A, Alhejazi A. Natural Killer/T-Cell lymphoma: Saudi Lymphoma Group's clinical practice guidelines for diagnosis, management and follow-up. Saudi J Med Med Sci 2019;7:222-5
|How to cite this URL:|
Motabi I, Alzahrani M, Dada R, Al-Mansour M, Alhashmi H, Kandil M, Sagheir A, Alhejazi A. Natural Killer/T-Cell lymphoma: Saudi Lymphoma Group's clinical practice guidelines for diagnosis, management and follow-up. Saudi J Med Med Sci [serial online] 2019 [cited 2019 Sep 20];7:222-5. Available from: http://www.sjmms.net/text.asp?2019/7/3/222/265638
| Introduction|| |
Natural killer/T-cell lymphoma (NKTCL) is a rare subtype of non-Hodgkin's lymphoma (NHL). According to the Saudi Cancer Registry, in 2015, 829 patients were diagnosed with NHL in Saudi Arabia, of which 24 patients (males = 14; females = 10) (2.9%) were diagnosed with mature T-cell lymphoma.
| Methods|| |
A committee comprising experts in hematology and medical oncology was established under the supervision of the Saudi Lymphoma Group and in collaboration with the Saudi Oncology Society. For collecting evidence, a literature search was carried out with relevant keywords using online database search engines such as PubMed/Medline, Web of Science and Scopus. In addition, expert opinion was considered when necessary. The levels of evidence used in developing this guideline were as follows:
- Evidence level (EL)-1 (highest), evidence from Phase III randomized trials or meta-analyses
- EL-2 (intermediate), evidence from well-designed Phase II trials or Phase III trials with limitations
- EL-3 (low), evidence from retrospective or observational studies/reports and/or expert opinion.
This easy-to-follow grading system is convenient for readers to understand and allows an accurate assessment of the guideline's applicability in individual patients.
1. PATHOLOGIC DIAGNOSIS (EL-1)
1.1. Incisional or excisional biopsy is the preferred method for the initial diagnosis of NKTCL.
1.2. Immunohistochemistry panel should include CD3, cytoplasmic CD3, CD56, CD20, CD2, CD4, CD5, CD7, CD8, CD30 and Ki-67.,,
1.3. The diagnosis of NKTCL is confirmed by histopathology features, typical immunophenotyping and documentation of active Epstein–Barr virus (EBV) infection.
1.4. Histopathology features are characterized by tissue necrosis and lymphomatous infiltrate of medium-sized or a mixture of small and large tumor cells.
1.5. Lymphoma cells are typically negative for surface CD3 and CD20, and positive for cytoplasmic CD3 and CD56. Tumor cells are also positive for cytotoxic molecules such as granzyme B, perforin and T-cell intracellular antigen 1.,
1.6. Documentation of EBV infection is a diagnostic requisite and should be determined by EBV–encoded RNA in situ hybridization.,,,, In addition to its diagnostic value, measurement of EBV DNA viral load by quantitative polymerase chain reaction (PCR) has a prognostic value and can also be used for monitoring and response to treatment.,
1.7. Cases with positive CD56 or cytotoxic molecules in the absence of EBV are classified as peripheral T-cell lymphoma, not otherwise specified (NOS), according to the world health organization (WHO) classification. Similarly, cases positive for EBV but negative for cytotoxic molecules are classified as EBV-positive peripheral T-cell lymphoma, NOS.,
1.8. Prognostic index: Although many prognostic scoring systems are available, the panel recommends using the PINK-E (prognostic index for NK/T-cell lymphoma-EBV DNA) scoring system (i.e., age, >60; Stages 3 or 4; distant lymph node involvement; non-nasal-type disease; and detectable EBV DNA titer).
2. DIAGNOSIS AND WORKUP (EL-3)
2.1. Evaluations should include detailed history including age, performance status, B symptoms, skin lesions and local ENT symptoms; and physical examination with attention to the oropharyngeal area including Waldeyer's ring, testicles and skin.
2.2. Routine laboratory workup including complete blood count, liver function test, kidney function test, electrolytes, uric acid and lactate dehydrogenase.
2.3. Hepatitis serology
2.4. Bone marrow biopsy is recommended for staging.
2.5. Computed tomography (CT) scan of the chest, abdomen and pelvis.
2.6. CT and magnetic resonance imaging of the neck, nasal cavity and nasopharynx should be performed in all cases.
2.7. Whole-body positron emission tomography scan is recommended, if available.
2.8. Cardiac function should be assessed by echocardiography or multigated acquisition scan.
2.9. Pregnancy test should be done for women of childbearing age.
2.10. Screening test for HIV is required.
2.11. Quantitative EBV DNA by PCR.
2.12. Complete ENT evaluation should be carried out.
There are no randomized controlled studies available to provide treatment guidelines for NKTCL. The best available data are extracted from retrospective reviews and phase II trials. The panel encourages referral of such cases to tertiary care centers.
3.1. Treatment of limited stage (Stages I and II)
Combined modality therapy is the standard and is associated with favorable long-term outcome in limited stage disease. NKTCL is a radiosensitive disease, and radiation therapy alone results in high overall response rate but with an unacceptably high rate of systemic relapse (up to 18%–40%).,,, Different combination regimens have been tested in phase II trials with excellent outcome but variable toxicity profiles. The following combined modalities protocols are associated with very good long-term outcome but were not compared in head-to-head studies:
3.1.1. Concurrent chemoradiation therapy (CCRT) and platinum-based chemotherapy:
126.96.36.199. CCRT–DeVIC: Radiotherapy with 50 Gy over 5–6 weeks started simultaneously with dexamethasone, etoposide, ifosfamide and carboplatin (DeVIC). DeVIC is given every 3 weeks for a total of three cycles (EL-2).,,
188.8.131.52. CCRT–VIPD: Radiotherapy with 40–52.8 Gy and weekly cisplatin followed by three cycles of etoposide, ifosfamide, cisplatin and dexamethasone (VIPD) (EL-2).,,
3.1.2. Sandwich chemoradiation:
184.108.40.206. Peg asparaginase, gemcitabine and oxaliplatin (P-GEMOX) or gemcitabine, L-asparaginase and oxaliplatin (GELOX) for two cycles followed by radiotherapy with 56 Gy and P-GEMOX or GELOX for a total of four to six cycles.
220.127.116.11. L-asparaginase, vincristine and dexamethasone (LVD) for two cycles followed by radiotherapy with 56 Gy and two to four cycles of LVD (EL-2).,,,
3.1.3. Sequential chemoradiation:
18.104.22.168. Modified dexamethasone, methotrexate, ifosfamide, L-asparaginase and etoposide (SMILE) for two to four cycles followed by radiotherapy with 45–50.4 Gy (EL-2).
The above-mentioned combined regimens have a long-term progression-free survival of about 70%–80%. The toxicity profile of the asparaginase-containing sandwich chemoradiation is better compared with the other CCRT regimens. The rates of severe mucositis and bone marrow suppression are higher with CCRT regimens. Additionally, after CCRT–DeVIC, late toxicities occur in about 50% of the patients, including a 5% incidence of secondary malignancy.
3.2. Treatment of advanced stage
Asparaginase-containing combination chemotherapy regimens are the standard treatment for advanced-stage NKTCL. The following regimens are recommended:
3.2.1. SMILE for four to six cycles (EL-3).,
3.2.2. Dexamethasone, gemcitabine, cisplatin and asparaginase for six cycles (EL-2).
3.2.3. Radiation therapy can be considered for nasal involvement in advanced-stage disease.
3.3. Treatment of relapse and refractory disease:
Asparaginase-containing regimens are effective for the treatment of relapsed NKTCL, even in patients with prior exposure to asparaginase. However, their efficacy in refractory disease is minimal, with only a 25% ORR. In these cases, the following regimens can be used:
3.3.1. L-asparaginase, methotrexate and dexamethasone (AspaMetDex) for 3 cycles (EL-2).
3.3.2. SMILE for four to six cycles (EL-2).,
3.3.3. P-GEMOX for two cycles (EL-2).,
3.3.4. In a small study where seven heavily pretreated patients were treated with pembrolizumab, a positive overall response was observed in five patients including three achieving complete remission. All responses were durable after a median follow-up of 6 months (EL-3).
3.3.5. Lenalidomide can be considered in patients who failed more than one line of therapy. There are no studies to support this recommendation but, in a retrospective study of a cohort of patients with relapsed/refractory NKTCL, durable remission was achieved in patients after lenalidomide treatment (EL-3).,
3.4. Role of hematopoietic stem cell transplantation
3.4.1. The role of hematopoietic stem cell transplantation (HSCT) is not defined in the treatment of NKTCL.
3.4.2. In the early stage disease, combined modality therapy is associated with excellent outcome. Upfront autologous HSCT is not recommended for this indication.
3.4.3. In advanced stage disease, the results of autologous HSCT in retrospective studies are not different from those observed in chemotherapy studies. Therefore, autologous HSCT is not recommended as first-line therapy in advanced stage NKTCL.
3.4.4. Patients with refractory disease have a very poor outcome after autologous HSCT.
3.4.5 SCT might not be necessary for patients who achieved complete remission after SMILE as upfront or salvage protocol, but it should be discussed for selected chemosensitive relapsed or refractory patients (EL-3).
4.1. History and physical examination every 3 months for 1 year, every 6 months for 2 years and then once a year.
4.2. CT examinations are required at 6, 12 and 24 months after the end of treatment.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Teras LR, DeSantis CE, Cerhan JR, Morton LM, Jemal A, Flowers CR. 2016 US lymphoid malignancy statistics by World Health Organization subtypes. CA Cancer J Clin 2016;66:443-59.
Saudi Cancer Registry. Cancer Incidence Report in Saudi Arabia 2015. Riyadh (KSA): Saudi Cancer Registry; 2018.
Jazieh AR; Saudi Lung Cancer Guidelines Committee. The lung cancer management guidelines 2012. J Infect Public Health 2012;5 Suppl 1:S4-10.
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al
. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (IARC WHO Classification of Tumours). Revised 4th
ed. Lyon: International Agency for Research on Cancer; 2017.
Kim SJ, Kim BS, Choi CW, Choi J, Kim I, Lee YH, et al.
Ki-67 expression is predictive of prognosis in patients with stage I/II extranodal NK/T-cell lymphoma, nasal type. Ann Oncol 2007;18:1382-7.
Yasuda H, Sugimoto K, Imai H, Isobe Y, Sasaki M, Kojima Y, et al.
Expression levels of apoptosis-related proteins and Ki-67 in nasal NK/T-cell lymphoma. Eur J Haematol 2009;82:39-45.
Asano N, Suzuki R, Kagami Y, Ishida F, Kitamura K, Fukutani H, et al.
Clinicopathologic and prognostic significance of cytotoxic molecule expression in nodal peripheral T-cell lymphoma, unspecified. Am J Surg Pathol 2005;29:1284-93.
Wong KF, Chan JK, Cheung MM, So JC. Bone marrow involvement by nasal NK cell lymphoma at diagnosis is uncommon. Am J Clin Pathol 2001;115:266-70.
Chim CS, Ma ES, Loong F, Kwong YL. Diagnostic cues for natural killer cell lymphoma: Primary nodal presentation and the role of in situ
hybridisation for Epstein–Barr
virus encoded early small RNA in detecting occult bone marrow involvement. J Clin Pathol 2005;58:443-5.
Huang WT, Chang KC, Huang GC, Hsiao JR, Chen HH, Chuang SS, et al.
Bone marrow that is positive for Epstein–Barr
virus encoded RNA-1 by in situ
hybridization is related with a poor prognosis in patients with extranodal natural killer/T-cell lymphoma, nasal type. Haematologica 2005;90:1063-9.
Lee J, Suh C, Huh J, Jun HJ, Kim K, Jung C, et al.
Effect of positive bone marrow EBV in situ
hybridization in staging and survival of localized extranodal natural killer/T-cell lymphoma, nasal-type. Clin Cancer Res 2007;13:3250-4.
Au WY, Pang A, Choy C, Chim CS, Kwong YL. Quantification of circulating Epstein–Barr
virus (EBV) DNA in the diagnosis and monitoring of natural killer cell and EBV-positive lymphomas in immunocompetent patients. Blood 2004;104:243-9.
Kim HS, Kim KH, Kim KH, Chang MH, Ji SH, Lim DH, et al.
Whole blood Epstein–Barr
virus DNA load as a diagnostic and prognostic surrogate: Extranodal natural killer/T-cell lymphoma. Leuk Lymphoma 2009;50:757-63.
de Leval L, Gaulard P. Pathology and biology of peripheral T-cell lymphomas. Histopathology 2011;58:49-68.
Kim SJ, Yoon DH, Jaccard A, Chng WJ, Lim ST, Hong H, et al.
A prognostic index for natural killer cell lymphoma after non-anthracycline-based treatment: A multicentre, retrospective analysis. Lancet Oncol 2016;17:389-400.
Au WY, Weisenburger DD, Intragumtornchai T, Nakamura S, Kim WS, Sng I, et al.
Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: A study of 136 cases from the international peripheral T-cell lymphoma project. Blood 2009;113:3931-7.
Li YX, Yao B, Jin J, Wang WH, Liu YP, Song YW, et al.
Radiotherapy as primary treatment for stage IE and IIE nasal natural killer/T-cell lymphoma. J Clin Oncol 2006;24:181-9.
Huang MJ, Jiang Y, Liu WP, Li ZP, Li M, Zhou L, et al.
Early or up-front radiotherapy improved survival of localized extranodal NK/T-cell lymphoma, nasal-type in the upper aerodigestive tract. Int J Radiat Oncol Biol Phys 2008;70:166-74.
Bi XW, Jiang WQ, Zhang WW, Huang JJ, Xia Y, Wang Y, et al.
Treatment outcome of patients with advanced stage natural killer/T-cell lymphoma: Elucidating the effects of asparaginase and postchemotherapeutic radiotherapy. Ann Hematol 2015;94:1175-84.
Yamaguchi M, Tobinai K, Oguchi M, Ishizuka N, Kobayashi Y, Isobe Y, et al.
Phase I/II study of concurrent chemoradiotherapy for localized nasal natural killer/T-cell lymphoma: Japan clinical oncology group study JCOG0211. J Clin Oncol 2009;27:5594-600.
Yamaguchi M, Tobinai K, Oguchi M, Ishizuka N, Kobayashi Y, Isobe Y, et al.
Concurrent chemoradiotherapy for localized nasal natural killer/T-cell lymphoma: An updated analysis of the Japan clinical oncology group study JCOG0211. J Clin Oncol 2012;30:4044-6.
Yamaguchi M, Suzuki R, Oguchi M, Asano N, Amaki J, Akiba T, et al.
Treatments and outcomes of patients with extranodal natural killer/T-cell lymphoma diagnosed between 2000 and 2013: A cooperative study in Japan. J Clin Oncol 2017;35:32-9.
Kim SJ, Kim K, Kim BS, Kim CY, Suh C, Huh J, et al.
Phase II trial of concurrent radiation and weekly cisplatin followed by VIPD chemotherapy in newly diagnosed, stage IE to IIE, nasal, extranodal NK/T-cell lymphoma: Consortium for improving survival of lymphoma study. J Clin Oncol 2009;27:6027-32.
Oh D, Ahn YC, Kim SJ, Kim WS, Ko YH. Concurrent chemoradiation therapy followed by consolidation chemotherapy for localized extranodal natural killer/T-cell lymphoma, nasal type. Int J Radiat Oncol Biol Phys 2015;93:677-83.
Tsai HJ, Lin SF, Chen CC, Chen TY, Su WC, Hwang WL, et al.
Long-term results of a phase II trial with frontline concurrent chemoradiotherapy followed by consolidation chemotherapy for localized nasal natural killer/T-cell lymphoma. Eur J Haematol 2015;94:130-7.
Wang L, Wang ZH, Chen XQ, Wang KF, Huang HQ, Xia ZJ. First-line combination of GELOX followed by radiation therapy for patients with stage IE/IIE ENKTL: An updated analysis with long-term follow-up. Oncol Lett 2015;10:1036-40.
Zhang L, Jiang M, Xie L, Zhang H, Jiang Y, Yang QP, et al.
Five-year analysis from phase 2 trial of “sandwich” chemoradiotherapy in newly diagnosed, stage IE to IIE, nasal type, extranodal natural killer/T-cell lymphoma. Cancer Med 2016;5:33-40.
Jing XM, Zhang ZH, Wu P, Zhang SC, Ren YR, Xiong ZJ, et al
. Efficacy and tolerance of pegaspargase, gemcitabine and oxaliplatin with sandwiched radiotherapy in the treatment of newly-diagnosed extranodal nature killer (NK)/T cell lymphoma. Leuk Res 2016;47:26-31.
Wang JH, Wang H, Wang YJ, Xia ZJ, Huang HQ, Jiang WQ, et al.
Analysis of the efficacy and safety of a combined gemcitabine, oxaliplatin and pegaspargase regimen for NK/T-cell lymphoma. Oncotarget 2016;7:35412-22.
Lunning M, Pamer E, Maragulia J, Straus D, Yahalom J, Moskowitz A, et al
. Modified SMILE (mSMILE) is active in the treatment of extranodal natural killer/T-cell lymphoma: A single center US experience. Clin Lymphoma Myeloma Leuk 2014;14:S143-4.
Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, et al
. Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: The NK-cell tumor study group study. J Clin Oncol 2011;29:4410-6.
Kwong YL, Kim WS, Lim ST, Kim SJ, Tang T, Tse E, et al.
SMILE for natural killer/T-cell lymphoma: Analysis of safety and efficacy from the Asia lymphoma study group. Blood 2012;120:2973-80.
Li X, Cui Y, Sun Z, Zhang L, Li L, Wang X, et al.
DDGP versus SMILE in newly diagnosed advanced natural killer/T-cell lymphoma: A randomized controlled, multicenter, open-label study in China. Clin Cancer Res 2016;22:5223-8.
Huang MJ, Jiang Y, Liu WP, Li ZP, Li M, Zhou L. Early or up-front radiotherapy improved survival of localized extranodal NK/T-cell lymphoma, nasal-type in the upper aerodigestive tract. Int J Radiat Oncol Biol Phys 2008;70:166-74.
Jaccard A, Gachard N, Marin B, Rogez S, Audrain M, Suarez F, et al.
Efficacy of L-asparaginase with methotrexate and dexamethasone (AspaMetDex regimen) in patients with refractory or relapsing extranodal NK/T-cell lymphoma, a phase 2 study. Blood 2011;117:1834-9.
Qi S, Yahalom J, Hsu M, Chelius M, Lunning M, Moskowitz A, et al.
Encouraging experience in the treatment of nasal type extra-nodal NK/T-cell lymphoma in a non-Asian population. Leuk Lymphoma 2016;57:2575-83.
Kwong YL, Chan TS, Tan D, Kim SJ, Poon LM, Mow B, et al
. PD1 blockade with pembrolizumab is highly effective in relapsed or refractory NK/T-cell lymphoma failing l-asparaginase. Blood 2017;129:2437-42.
Davies F, Baz R. Lenalidomide mode of action: Linking bench and clinical findings. Blood Rev 2010;24 Suppl 1:S13-9.
Dueck G, Chua N, Prasad A, Finch D, Stewart D, White D, et al.
Interim report of a phase 2 clinical trial of lenalidomide for T-cell non-Hodgkin lymphoma. Cancer 2010;116:4541-8.