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ORIGINAL ARTICLE
Year : 2016  |  Volume : 4  |  Issue : 3  |  Page : 187-191

Etiology of recurrent pregnancy loss in Saudi females


Department of Obstetrics and Gynecology, King Fahd Hospital of the University, University of Dammam, Al-Khobar, Saudi Arabia

Correspondence Address:
Ahlam A Al-Ghamdi
Department of Obstetrics and Gynecology, King Fahd Hospital of the University, University of Dammam, P.O. Box 2208, Al-Khobar 31952
Saudi Arabia
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DOI: 10.4103/1658-631X.188258

PMID: 30787727

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Objective: The aim of our retrospective study was to assess the etiology of recurrent pregnancy loss (RPL) in Saudi couples attending a specialized RPL clinic at King Fahad Hospital of the University, Al-Khobar, Saudi Arabia. Patients and Methods: A total of 59 couples attending the RPL clinic between January 2010 and December 2013 and who had completed their workup and investigations for RPL were included in the study. Data were collected from patients' charts and computer-based laboratory results. Results: Protein S deficiency was found in 47% of patients, a chromosomal abnormality in 6.7%, uterine abnormality in 12%, antiphospholipid syndrome (APS) in 12%, and antithrombin III and Protein C deficiency in 1.7%. However, no patient had Factor V Leiden mutation. In 39% of the patients, there was no identifiable cause, and therefore, they had been diagnosed as unexplained RPL. Conclusion: The most common cause of RPL was Protein S deficiency followed by congenital uterine anomalies and APS. Almost 40% of couples with RPL remain with unknown etiology.


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